4-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione → HCID 178518363, compound

HRID 2236879Notes

Reaction equation

HRID 2236879 reaction equation
OC1C=C([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])C=CC=1C1C=CC=CC=1.IC1C=C2C(=CC=1)C(=O)[NH:36][C:35](=O)C2=COC.NC[C:48]1[CH:49]=[CH:50][C:51]([C:55]2[CH:60]=[CH:59][CH:58]=CN=2)=[C:52]([OH:54])[CH:53]=1>>[OH:54][C:52]1[CH:53]=[C:48]([CH:49]=[CH:50][C:51]=1[C:55]1[CH:35]=[N:36][CH:58]=[CH:59][CH:60]=1)[CH2:8][NH:9][CH:10]=[C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=2)[C:14](=[O:22])[NH:13][C:12]1=[O:23]

Participants

4

Reactant 3

HCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dioneHCID 135922726HCID 135922726, compoundHCID 178518360HCID 178518360, compound

Product 1

HCID 178518363HCID 178518363, compoundYield 76%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (50 mg, 0.15 mmol) and 5-Aminomethyl-2-pyridin-2-yl-phenol (53 mg, 0.27 mmol) in 76% yield: MS (ESI): 498.0 (M+1)+1.

Sources & evidence

ORD record
ord-607e20d8b86d4fc4bbd02a728791d29c
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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