Sodium periodate → HCID 42625746, compound

Participants

Reaction Steps

To a solution of 4-(2-dimethylamino-vinyl)-1-furan-3-yl-1H-pyridin-2-one (21 mmol) in 50% aqueous tetrahydrofuran (700 mL) is added sodium periodate (13 g, 63 mmol). After six hours of stirring at room temperature, the reaction mixture is filtered. The filtrate is washed 3× with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to provide 1-furan-3-yl-2-oxo-1,2-dihydro-pyridine-4-carbaldehyde as a yellow powder (2.1 g, 53% over 2 steps).

Provenance & Evidence