Triethylamine → HCID 178514717, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-Methoxymethylene-4H-isoquinoline-1,3-dione (507 mg, 2.5 mmol) in N,N-dimethylformate (250 μL) is added 4-aminoethylbenzene sulfonylamide hydrochloride (556 mg, 2.5 mmol) and triethylamine (525 μL). The reaction mixture is shaken at 115° C. for 1.5 hours, then concentrated. Ethyl acetate is added to the solid residue that remained and the solid is recovered by filtration, rinsing with diethyl ether, and drying to yield 660.8 mg of 4-{[(1,3-Dioxo-2,3-dihydro-1H-isoquinolin-4-ylidenemethyl)-amino]-methyl}benzenesulfonamide.

Provenance & Evidence