Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(Aminomethyl)benzene-1,2-diol--hydrogen bromide (1/1) | HCID 13343562 | — |
| Reactant | 4-methoxymethylene-6-bromo-4H-isoquinoline-1,3-dione | HCID 68692764 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178419745 | HCID 178419745 | 195.7% |
Reaction Steps
To a suspension of crude 6-Bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (846 mg, 3 mmol) in N,N-dimethylformamide (7.5 mL) is added 3,4-dihydroxy benzylamine hydrobromide (660 mg, 3 mmol) and triethylamine (630 μL, 4.5 mmol). The reaction mixture is shaken at 115° C. for 1.5 hours. Upon cooling to room temperature, the product precipitated out. The precipitate is then filtered off, rinsed with copious amounts of ether, and dried to yield 1.38 g of 6-Bromo-4-[(3,4-dihydroxy-benzylamino)-methylene]-4H-isoquinoline-1,3-dione hydrobromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07713994B2 |
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| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-ef5cc7bff6d94c758ce1b87bdd2f7b42 |
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| Source note | uspto-grants-2010_05 |
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