Sodium Iodide → HCID 178480726, compound

Participants

Reaction Steps

To a solution of 4-{[4-(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-6-(1H-pyrrol-3-yl)-4H-isoquinoline-1,3-dione (42 mg, 0.1 mmol) in acetone (3 mL) and N,N-dimethylformamide (1 mL) is added potassium carbonate (27 mg, 0.2 mmol) and shaken at room temperature for 2 hours. This is followed by addition of sodium iodide (30 mg, 0.2 mmol) and 2-bromoacetamide (17 mg, 0.12 mmol) and further shaking at room temperature overnight. The reaction mixture is then divided into 2 fractions and purified by C18 reverse phase HPLC. The pure fractions were combined and concentrated to yield the title compound (8.4 mg).

Provenance & Evidence