HRID2236968

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID63943447

未命名化合物

结构：CCCCNc1cc(OCCN2CCN(C(=O)OC(C)(C)C)CC2)ccc1N

HCID66977666

未命名化合物

PRODUCTS

生成物

结构：CCCCn1c(-c2cccc(Oc3cccc(C(C)(C)C)c3)c2)nc2ccc(OCCN3CCNCC3)cc21

HCID59699164

未命名化合物

PROCEDURE

实验过程

A mixture of 1-BOC-4-[2-(4-amino-3-butylamino-phenoxy)-ethyl]-piperazine (synthesized via General Procedures G1 and G2 and H) (0.130 g, 0.512 mmol) and 3-(3-tert-butylphenoxy)benzaldehyde was subjected to General Procedure K. Reaction was concentrated and purified on silica gel-chromatography using DCM-2% MeOH/DCM. The BOC-group was removed employing General Procedure T1 to give 1-butyl-2-{3-[3-tert-butyl-phenoxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole (0.10 g).

WORKUP

后处理

customReaction
concentrationwas concentrated
custompurified on silica gel-chromatography
customThe BOC-group was removed

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a40711c7956d470dbe2dad04e04d6a2f
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07714013B2
来源说明: uspto-grants-2010_05

反应 SMILES

C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[C:19]([NH:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:18]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[C:29]([C:33]1[CH:34]=[C:35]([CH:45]=[CH:46][CH:47]=1)[O:36][C:37]1[CH:38]=[C:39]([CH:42]=[CH:43][CH:44]=1)[CH:40]=O)([CH3:32])([CH3:31])[CH3:30]>>[CH2:25]([N:24]1[C:19]2[CH:18]=[C:17]([O:16][CH2:15][CH2:14][N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:22]=[CH:21][C:20]=2[N:23]=[C:40]1[C:39]1[CH:42]=[CH:43][CH:44]=[C:37]([O:36][C:35]2[CH:45]=[CH:46][CH:47]=[C:33]([C:29]([CH3:32])([CH3:31])[CH3:30])[CH:34]=2)[CH:38]=1)[CH2:26][CH2:27][CH3:28]