HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 7-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate → tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 7-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 6420695 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 22061016 | — |
Reaction Steps
The nitro compound obtained above (4.1 g, 14.7 mmol) was dissolved in MeOH (80 mL) and hydrogenated in the presence of 10% Pd/C (0.3 g), according to General Procedure H. Workup afforded 7-amino-2-Boc-1,2,3,4-tetrahydroisoquinoline (2-Boc-TIQ aniline (3.6 g, 98% yield) as a light-brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714013B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-0656552649054386af21d7355bed5be0 |
| Source note | uspto-grants-2010_05 |