HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → HCID 66977502, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | 1-(4-Fluoro-1-naphthyl)ethan-1-one | HCID 67568 | — |
| Reactant | Carbonyl bromide | HCID 79057 | — |
| Reactant | tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 22061016 | — |
| Reactant | HCID 66977636 | HCID 66977636 | — |
| Product | HCID 66977502 | HCID 66977502 | — |
| Product | HCID 66977636 | HCID 66977636 | — |
Reaction Steps
4′-(4-chlorophenoxy)-1′-acetonaphthone was prepared from 4′-fluoro-1′-acetonaphthone and 4-chlorophenol following general procedure Q2. 4′-(4-chlorophenoxy)-1′-acetonaphthone was brominated following general procedure R1. The bromo ketone was condensed with 7-amino-2-Boc-1,2,3,4-tetrahydroisoquinoline following general procedure R2. The aminoketone intermediate was treated with n-penatnoyl chloride accoding to general procedure R3. The product amide was then subjected to imidazole formation employing general procedure R4. The BOC group of the product was removed employing general procedure T1 to afford 7-{2-Butyl-4-[4-(4-chloro-phenoxy)-naphthalen-1-yl]-imidazol-1-yl}-1,2,3,4-tetrahydro-isoquinoline hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714013B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-ccae1ad9081742e884a93badb4177d54 |
| Source note | uspto-grants-2010_05 |