[3,5-bis(trifluoromethyl)phenyl]methanesulfonyl Chloride → HCID 21962336, compound

HRID 2237078Notes

Reaction equation

HRID 2237078 reaction equation
[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38]S(CC1C=CC=CC=1)(=O)=O)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:49][C:50]([F:67])([F:66])[C:51]1[CH:52]=[C:53]([CH:59]=[C:60]([C:62]([F:65])([F:64])[F:63])[CH:61]=1)[CH2:54][S:55](Cl)(=[O:57])=[O:56]>>[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=2)[C:16]([CH2:24][CH2:25][O:26][C:27]2[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)=[C:15]1[CH2:36][CH2:37][NH:38][S:55]([CH2:54][C:53]1[CH:52]=[C:51]([C:50]([F:67])([F:66])[F:49])[CH:61]=[C:60]([C:62]([F:65])([F:64])[F:63])[CH:59]=1)(=[O:57])=[O:56])([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 3732866[3,5-bis(trifluoromethyl)phenyl]methanesulfonyl ChlorideHCID 9874688HCID 9874688, compound

Product 1

HCID 21962336HCID 21962336, compoundYield 79%

Procedure

To the methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate (Step 6, Example 1) was added 3,5-bis(trifluoromethyl)benzylsulfonyl chloride according to the procedure in Example 1 Step 7 to generate the product in 79% yield.

Sources & evidence

ORD record
ord-fab1d79030a944d5b9b92d84c4d5aa10
Source dataset
uspto-grants-2010_05
Patent number
US07713964B2

Reaction notes

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