HCID 12941212, compound → HCID 12941228, compound

HRID 223722Notes

Reaction equation

HRID 223722 reaction equation
C([N:11]1[CH2:18][C:17]([OH:25])([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:16][C@H:12]1[C:13]([OH:15])=[O:14])(OCC1C=CC=CC=1)=O>[C].[Pd]>[OH:25][C:17]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:18][NH:11][C@H:12]([C:13]([OH:15])=[O:14])[CH2:16]1

Participants

3

Reactant 1

HCID 12941212HCID 12941212, compound2×

Product 1

HCID 12941228HCID 12941228, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

A solution of the N-carbobenzyloxy-4-hydroxy-4-phenyl-L-proline from part (a) is treated with a 5% palladium carbon catalyst and hydrogenated according to the procedure of Example 1(b) to yield 4-hydroxy-4-phenyl-L-proline.

Sources & evidence

ORD record
ord-458ec1525af1426a98c28f271f4b487a
Source dataset
uspto-grants-1982_10
Patent number
US04356182

Reaction notes

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