HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2237296Generated: October 30, 2026
4-Fluoroaniline → 1-(4-Fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid
https://huagongshe.com/reaction/2237296
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid | HCID 4182007 | — |
Reaction Steps
To a solution of 6,6-dimethyl-5,7-dioxaspiro[2.5]-octane-4,8-dione (Aldrich, 51 mg, 0.3 mmol) in DMF (0.5 mL) at room temperature was added 4-fluoroaniline (Aldrich, 33 mg, 0.3 mmol). The reaction mixture was heated at 90° C. for 2 h, cooled to room temperature, and used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07714138B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-bef450bd44614d81803e4b0ec2404619 |
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| Source note | uspto-grants-2010_05 |
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