反应详情

N-hydroxysuccin imide (1.58 g, 13.8 mmol) and succinic mono-(2-{2-[2-(2-allyloxy-ethoxy)-ethoxy]-ethoxy}-ethyl) ester (10) (4.6 g, 13.76 mmol) were dissolved in dry CH2Cl2 (10 mL) at room temperature. A solution of N,N′-dicyclohexylcarbodiimide (DCC) (2.84 g, 13.8 mmol) in dry CH2Cl2 (2 mL) was slowly added to the mixture at 0° C. The resulting mixture was stirred at room temperature for 2 hours. The solid residues in the reaction mixture were filtered through a sintered glass filter and removed and the filtrate was concentrated to obtain the target compound in a yellow oily phase (5.5 g, 93%). The compound was used without further purification. The NMR analysis result of the product is as follows.

1. filtrationThe solid residues in the reaction mixture were filtered through a sintered glass
2. filtrationfilter
3. customremoved
4. concentrationthe filtrate was concentrated