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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 223737Generated: October 25, 2026

Acetylthioacetylchloride → (2S)-1-[2-(acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid

https://huagongshe.com/reaction/223737

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetylthioacetylchlorideHCID 23301560—
ReactantN-carbobenzyloxy-4-[(2-furyl)methyl]-4-hydroxy-L-prolineHCID 54161613—
Reactant(2S)-1-[2-(Acetylthio)-1-oxoethyl]-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acidHCID 57067544—
Product(2S)-1-[2-(acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acidHCID 57078237—

Reaction Steps

4-[(2-Furyl)methyl]-3,4-dehydro-L-proline from part (a) is reacted with 2-acetylthioacetyl chloride according to the procedure of Example 3 (b) to yield (2S)-1-[2-(acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04356182
Source datasetuspto-grants-1982_10
ORD IDord-1e898a842eb54e96a8b4c5311cd43ad6
Source noteuspto-grants-1982_10