HCID 10882014, compound → HCID 59302375, compound

Participants

Reaction Steps

A mixture of methyl N-(benzyloxycarbonyl)-3-(6-methylpyridin-2-yl)-L-alaninate (7.25 g, 22.1 mmol) [S. W. Jones, C. F. Palmer, J. M. Paul, P. D. Tiffin, Tetrahedron Lett. 1999, 40, 1211-1214] and 10 percent palladium on carbon (0.690 g) in ethanol (80 ml) is hydrogenated at RT and under atmospheric pressure for 1 h. The reaction mixture is passed through a syringe filter (Millipore, 0.45 μg, hydrophobic PTFE) which is washed with ethanol (2×10 ml). The residue is concentrated on a rotary evaporator (removal of solvent residues by entrainment with toluene, twice) and dried under high vacuum. The product is obtained as an oil (3.89 g, yield 91% of theory).

Provenance & Evidence