Tetrahydrofuran → HCID 403201, compound

Participants

Reaction Steps

100 mg (1.76 mmol) sodium methoxide and 300 mg (0.571 mmol) tert.butyl 4-(7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl)-piperazine-1- carboxylate are suspended in 5 ml of tetrahydrofuran, then placed in the microwave for 0.1 hours at 120° C. Then the reaction mixture is concentrated by evaporation, the residue is combined with methanol and suction filtered. The mother liquor is concentrated by evaporation, then extracted with water and dichloromethane. The organic phase is dried and evaporated to dryness. The residue is purified by chromatography. Corresponding fractions are concentrated by evaporation and crystallised from diethyl ether.

Provenance & Evidence