Ethyl Acetate → 1-(4-methoxybenzyl)-1H-indazol-4-amine

Participants

Reaction Steps

A suspension of 1-(4-methoxybenzyl)-4-nitro-1H-indazole (9 g, 31.77 mmol) and platinum(IV) oxide (0.433 g, 1.91 mmol) in ethanol (150 mL)/ethyl acetate (10 mL) was hydrogenated under 40 psi at 25° C. for 2 hours. The resulting mixture was filtered and the filtrate was concentrated to dryness to afford 1-(4-methoxybenzyl)-1H-indazol-4-amine (8.03 g, 100%) as a yellow-orange solid. Mass spectrum: MH+ 254.

Provenance & Evidence