HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 1,1-Dimethylethyl 2-bromo-4,5,7,8-tetrahydro-6H-thieno[2,3-d]azepine-6-carboxylate | HCID 59302551 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 2-BROMO-5,6,7,8-TETRAHYDRO-4H-THIENO[2,3-D]AZEPINE | HCID 11535969 | — |
Reaction Steps
The product of step g) (0.39 mmol) dissolved in ether (1 ml) was treated with 4 M HCl/dioxane (1 ml). The reaction mixture was stirred for 18 hours at ambient temperature. The resulting precipitate was filtered and washed with anhydrous diethyl ether to give the title compound as its HCl salt. 1H NMR (300 MHz, DMSO) δ 9.40 (s, 2H), 7.05 (s, 1H), 3.14-3.33 (m, 4H), 2.94-3.23 (m, 2H), 2.76-3.06 (m, 2H). MS: ESI (positive): 232, 234 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718647B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-1284d3a8d0b544cc8440ba1055830255 |
| Source note | uspto-grants-2010_05 |