Tetrahydrofuran → HCID 59302561, compound

Participants

Reaction Steps

The product of step b) (2.3 g, 7.3 mmol) was dissolved in 60 mL of 1:1 MeOH:THF. Diisopropylethylamine (1.9 mL, 10.9 mmol) was added followed by TMSCHN2 (10.9 mL of 2M). The reaction was stirred overnight at room temperature then quenched carefully with 0.4 ML HOAc. After stirring ½ hour, the reaction was partitioned between DCM and 1M HCl (100 mL each). The organic layer was dried over MgSO4 and concentrated to give 2.75 g of the subtitle compound.

Provenance & Evidence