Lithium Chloride → HCID 59302564, compound

Participants

Reaction Steps

The product of step c) (2.5 g, 7.8 mmol) was dissolved in 125 mL dry THF and treated with LiCl (0.65 g, 15.3 mmol) followed by LiBH4 (15.3 mL of 2M). After stirring for 1 hour, the reaction was quenched carefully with EtOH and HOAc till no gas evolution was observed. The crude reaction mixture was partitioned between water and DCM. The organic extract was dried over MgSO4 and concentrated to give 2.3 g of a clear oil which was purified by silica chromatography (30% EtOAc/Hex) to give 1.03 g of the subtitle compound.

Provenance & Evidence