HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 2-Bromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-Methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester | HCID 59302556 | — |
| Solvent | Acetic acid chloroform | HCID 21584526 | — |
| Product | 2-Bromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester | HCID 58945257 | — |
Reaction Steps
The product of step d) (80 mg, 0.35 mmol) was dissolved in 2 mL of 1:1 CHCl3 /HOAc. N-Bromo-succinimide (62 mg, 0.35 mmol) was added and the reaction was stirred for 15 minutes. Concentration and purification by silica gel chromatography gave the subtitle compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718647B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-d8df256afe024f1a99f98e7e868cde81 |
| Source note | uspto-grants-2010_05 |