反应详情

温度

63 °C

Furan-2-yl-oxo-acetic acid (15 g, 107 mmol), dissolved in CHCl3 (420 ml), was treated with EtOH (9.6 ml, 165 mmol) and H2SO4 (1 ml) and heated to 63° C. for 12 hours. Next, the reaction mixture was transferred to a separatory funnel and washed with sat. NaHCO3 (100 ml). The organic layer was washed with brine (100 ml), dried (MgSO4) and concentrated providing 16.9 g (66%) of the above subtitle compound, which was carried forward without further purification.

1. customNext, the reaction mixture was transferred to a separatory funnel
2. washwashed with sat. NaHCO3 (100 ml)
3. washThe organic layer was washed with brine (100 ml)
4. dry with materialdried (MgSO4)
5. concentrationconcentrated