反应详情

A solution of the product from step a.) (25 g, 135 mmol) in EtOH (250 ml) was cooled to 0° C. and treated with a solution of NaBH4 (2.5 g, 66 mmol) in H2O (27 ml) for 5 minutes. Next, the reaction mixture was quenched with AcOH (17 ml) and H2O (271 ml) and concentrated to dryness. The crude oil was dissolved in CH2Cl2 (300 ml), washed with brine (2×100 ml), dried (MgSO4) and concentrated providing 17.5 g (70%) of the above subtitle compound, which was carried forward without further purification.

1. customNext, the reaction mixture was quenched with AcOH (17 ml) and H2O (271 ml)
2. concentrationconcentrated to dryness
3. dissolutionThe crude oil was dissolved in CH2Cl2 (300 ml)
4. washwashed with brine (2×100 ml)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated