4-Fluorophenylboronic acid → HCID 68581963, compound

HRID 2237479Notes

Reaction equation

HRID 2237479 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[NH:7][S:6]1(=[O:16])=[O:15].[F:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:21]2[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=2)[S:6]1(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 442494893-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

Product 1

HCID 68581963HCID 68581963, compound

Procedure

In an analogous manner to Example 1 step 7, 3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (417 mg) was coupled to p-fluorophenylboronic acid to provide 3-(3-chloropropyl)-1-(4-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (67 mg):

Sources & evidence

ORD record
ord-87d7d5d94209430ea57e2e70313dfb65
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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