Tolylboronic acid → HCID 44249490, compound

HRID 2237481Notes

Reaction equation

HRID 2237481 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[NH:7][S:6]1(=[O:16])=[O:15].B(O)(O)[C:18]1[CH:19]=[CH:20][C:21]([CH3:24])=[CH:22][CH:23]=1>>[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)[S:6]1(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 79799Tolylboronic acidHCID 442494893-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

Product 1

HCID 44249490HCID 44249490, compound

Procedure

In an analogous manner to Example 1 step 7, 3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (408 mg) was coupled to p-tolylboronic acid to provide 3-(3-chloropropyl)-1-(4-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (99 mg):

Sources & evidence

ORD record
ord-9ae71337eb7f4024a6ce34dbe9408458
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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