3,4-Difluorobenzeneboronic acid → HCID 68583107, compound

HRID 2237485Notes

Reaction equation

HRID 2237485 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[NH:7][S:6]1(=[O:16])=[O:15].[F:17][C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][C:23]=1[F:24]>>[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:21]2[CH:20]=[CH:19][C:18]([F:17])=[C:23]([F:24])[CH:22]=2)[S:6]1(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 27343373,4-Difluorobenzeneboronic acidHCID 442494893-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

Product 1

HCID 68583107HCID 68583107, compound

Procedure

In an analogous manner to Example 1 step 7, 3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (474 mg) was coupled to 3,4-difluorophenylboronic acid to provide 3-(3-chloropropyl)-1-(3,4-difluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (92 mg):

Sources & evidence

ORD record
ord-1ec5f0f27d954114be7a1a69b1d1be2e
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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