Ethanol, 1-bromo- → 3-(2-bromoethyl)-6-fluoro-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide
Reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[F:17])[S:9](=[O:19])(=[O:18])[NH:8][CH2:7][C:6]=2[CH:20]=1.[Br:21][CH:22](O)[CH3:23]>>[Br:21][CH2:22][CH2:23][N:8]1[CH2:7][C:6]2[CH:20]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=2[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[S:9]1(=[O:19])=[O:18]Participants
3
Procedure
In an analogous manner to Example 11 step 4, a solution of 6-fluoro-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (1.01 g, 3.4 mmol) was reacted with bromoethanol (0.95 mL, 13.4 mmol) to afford 3-(2-bromoethyl)-6-fluoro-1-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (0.943 g, 69%) as white solid:
Sources & evidence
- ORD record
- ord-1826c249bddd45ce9cb83883cd55974a
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07718652B2
Reaction notes
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