反应详情

温度

50 °C

A solution of 2-fluoro-N-(2-nitrobenzyl)aniline (9.8 g, 40 mmol) in ethanol (200 mL) was treated with a solution of ammonium chloride (11 g, 66 mmol) in H2O (200 mL) and zinc dust (40 g, 66 mmol), and the reaction mixture was stirred at 50° C. for 2 h. The reaction mixture was filtered, diluted with ethyl ether (1 L), washed with H2O (1 L) and evaporated to provide N-(2-aminobenzyl)-2-fluoroaniline (8 g) as a pink solid:

1. filtrationThe reaction mixture was filtered
2. additiondiluted with ethyl ether (1 L)
3. washwashed with H2O (1 L)
4. customevaporated