2-Bromobutan-1-ol → HCID 68582542, compound

HRID 2237516Notes

Reaction equation

HRID 2237516 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][C:12]2[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=2[NH:10][S:9]1(=[O:19])=[O:18].[Br:20][CH:21](CC)[CH2:22]O>>[Br:20][CH2:21][CH2:22][N:10]1[C:11]2[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=2[CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[S:9]1(=[O:19])=[O:18]

Participants

3

Reactant 2

HCID 133988292-Bromobutan-1-olHCID 68581770HCID 68581770, compound

Product 1

HCID 68582542HCID 68582542, compoundYield 48.3%

Procedure

In an analogous manner to example 25, step 4, 3-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (0.24 g, 0.86 mmol) was treated with 2-bromobutanol (0.073 mL g, 1.0 mmol) to give 1-(2-bromoethyl)-3-(2-fluorophenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (0.16 g, 48%).

Sources & evidence

ORD record
ord-f149f09e296045f092feda7282162298
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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