[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → N-{4-[2-(4-benzoyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-4-chloro-benzamide

Participants

Role	Name	HCID	Charge
Reactant	[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid	HCID 677042	—
Reactant	1-Benzoylpiperazine	HCID 762654	—
Product	N-{4-[2-(4-benzoyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-4-chloro-benzamide	HCID 59698849	—

Reaction Steps

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with phenyl-piperazin-1-yl-methanone (CAS 13754-38-6) to give N-{4-[2-(4-benzoyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-4-chloro-benzamide, using general procedure C. White solid. MS 469.3 ([M+H]+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07718659B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-ce7ee8c95bf74612930994c47711fe6a
Source note	uspto-grants-2010_05