HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((Pyrrolidine-1-carbonyl)methyl)piperazine → (4-{2-Oxo-2-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-thiazol-2-yl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((Pyrrolidine-1-carbonyl)methyl)piperazine | HCID 100614 | — |
| Reactant | 2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)acetic acid | HCID 15480006 | — |
| Product | (4-{2-Oxo-2-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-thiazol-2-yl)-carbamic acid tert-butyl ester | HCID 59698829 | — |
Reaction Steps
37.3 Using general procedure C, (2-tert-butoxycarbonylamino-thiazol-4-yl)-acetic acid was coupled with 1-(pyrrolidinocarbonylmethyl)piperazine to give (4-{2-oxo-2-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-thiazol-2-yl)-carbamic acid tert-butyl ester. White solid. MS 460.4 ([M+Na]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718659B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-0e9587099f7f45738b50646789ac838d |
| Source note | uspto-grants-2010_05 |