HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-thiophenecarboxylic acid → {3-[(5-Chloro-thiophene-2-carbonyl)-amino]-pyrazol-1-yl}-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Reactant | ethyl 2-(3-amino-1H-pyrazol-1-yl)acetate | HCID 5200378 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | {3-[(5-Chloro-thiophene-2-carbonyl)-amino]-pyrazol-1-yl}-acetic acid ethyl ester | HCID 42643125 | — |
Reaction Steps
57.2 Using general method A, with THF instead of DMF as solvent, (3-amino-pyrazol-1-yl)-acetic acid ethyl ester was coupled with 5-chlorothiophene-2-carboxylic acid to give {3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrazol-1-yl}-acetic acid ethyl ester. Light yellow solid. MS 314.0 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718659B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-39216eff09ae4b5bb9e81b5a93c81cba |
| Source note | uspto-grants-2010_05 |