1-(4-Amino-3-fluorophenyl)pyridin-2-one → HCID 11561914, compound

HRID 2237569Notes

Reaction equation

HRID 2237569 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[N:14]=[CH:13][N:12]([CH2:15][C:16]([OH:18])=O)[N:11]=2)=[O:8])=[CH:4][CH:3]=1.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]2=[O:32])=[CH:22][C:21]=1[F:33]>>[F:33][C:21]1[CH:22]=[C:23]([N:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]2=[O:32])[CH:24]=[CH:25][C:20]=1[NH:19][C:16]([CH2:15][N:12]1[CH:13]=[N:14][C:10]([NH:9][C:7]([C:5]2[S:6][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:8])=[N:11]1)=[O:18]

Participants

3

Reactant 2

HCID 221815481-(4-Amino-3-fluorophenyl)pyridin-2-oneHCID 59698827{3-[(5-Chloro-thiophene-2-carbonyl)-amino]-[1,2,4]triazol-1-yl}-acetic acid

Product 1

HCID 11561914HCID 11561914, compound

Procedure

61.4 According to general method B, {3-[(5-chloro-thiophene-2-carbonyl)-amino]-[1,2,4]triazol-1-yl}-acetic acid was reacted with 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one (CAS 536747-52-1, prepared according to C. F. Bigge et al., patent application WO 2003045912) to give 5-chloro-thiophene-2-carboxylic acid (1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-1H-[1,2,4]triazol-3-yl)-amide. Off-white solid. MS 473.4 ([M+H]+)

Sources & evidence

ORD record
ord-e3f5875e93844ae69a1e78192a4efd9c
Source dataset
uspto-grants-2010_05
Patent number
US07718659B2

Reaction notes

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