Phosgene → 4-Methylpiperidine-1-carbonyl Chloride

Participants

Reaction Steps

9 g (90.75 mmol) of 4-methylpiperidine and 13.9 ml (100 mmol) of triethylamine were added at −30° C. to 54.9 ml (100 mmol) of phosgene in toluene (20 percent) and 100 ml of THF and, after stirring for 2.5 h, the reaction mixture was allowed to warm to room temperature. The reaction mixture was concentrated and the residue was mixed with methylene chloride and filtered off, and the filtrate was concentrated. The crude product (12.7 g) was reacted without further purification.

Provenance & Evidence