Water → HCID 178423436, compound

Participants

Reaction Steps

To a solution of 4.53 g of N4-[(1S,2R)-2-aminocyclohexyl]-6-methylquinazoline-2,4-diamine in 90 ml of methylene chloride, 5.18 g of N,N′-bis(t-butoxycarbonyl)-1H-pyrazole-1-carboxamidine was added, and then the mixture was stirred at room temperature for 15 hours. The reaction solution was mixed with water, extracted with methylene chloride and then dried. The solvent was distilled off and the residue was purified by silica gel column chromatography (chloroform:methanol=20:1) to obtain 8.50 g of the desirable compound.

Provenance & Evidence