Sodium Hydroxide → HCID 178423396, compound

Participants

Reaction Steps

To a solution of 14.56 q of 4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid ethyl ester in 350 ml of tetrahydrofuran, 55 ml of a 10% sodium hydroxide solution was added under ice cooling, and then the mixture was stirred at room temperature for 10 hours. The reaction solution was mixed with 170 ml of a 10% potassium hydrogensulfate solution, extracted with chloroform and then dried over magnesium sulfate. The solvent was distilled off to obtain 14.2 g of the desirable compound as a yellow powder.

Provenance & Evidence