Isobutylamine → HCID 178423394, compound

Participants

Reaction Steps

To a solution of 400 mg of 4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid, 0.15 ml of isobutylamine, 285 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 200 mg of 1-hydroxybenzotriazole in 7 ml of N,N′-dimethylformamide, 0.41 ml of triethylamine was added, and then the mixture was stirred at room temperature for 24 hours. The reaction solution was mixed with water and then extracted with ethyl acetate. The organic layer was washed with water and saturated brine and then dried over magnesium sulfate. The solvent was distilled off and the residue was purified by silica gel column chromatography (chloroform) to obtain 242 mg of the desirable compound as a white powder.

Provenance & Evidence