4-Phenoxyphenethylamine → N-(4-PHENOXYPHENETHYL)THIOUREA

HRID 2237608Notes

Reaction equation

C(OC1C=C([NH:15][C:16](N)=[S:17])C=CC=1)C1C=CC=CC=1.[O:19]([C:26]1[CH:34]=[CH:33][C:29]([CH2:30][CH2:31][NH2:32])=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[O:19]([C:26]1[CH:27]=[CH:28][C:29]([CH2:30][CH2:31][NH:32][C:16]([NH2:15])=[S:17])=[CH:33][CH:34]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

Reactant 2

HCID 1455354-Phenoxyphenethylamine

HCID 5277304HCID 5277304, compound

Product 1

HCID 11459969N-(4-PHENOXYPHENETHYL)THIOUREA

Procedure

This compound is prepared via a method analogous to the method for preparation of N-(3-benzyloxyphenyl)thiourea using 4-phenoxyphenethylamine as the starting material. 1H NMR (CDCl3, δ): 2.92 (t, J=6.9 Hz, 2H), 3.31-3.90 (m, 2H), 5.65 (s, 2H), 5.85-6.16 (m, 1H), 6.97-7.04 (m, 4H), 7.11-7.15 (m, 1H), 7.19 (d, J=7.4 Hz, 2H), 7.36 (t, J=7.8 Hz, 2H); LCMS (M+1): 273

Sources & evidence

ORD record: ord-f4090458f7b1492b9f94c1a756042743
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07718671B2

Reaction notes

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