HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylbenzylamine → N-Benzyl-2-fluoro-N-methyl-4-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-Benzyl-2-fluoro-N-methyl-4-nitroaniline | HCID 59302854 | 67% |
Reaction Steps
A solution of 1,2-difluoro-4-nitro-benzene (0.96 g, 6.0 mmole) and benzyl methylamine (0.79 g, 6.6 mmole) in 4 mL of anhydrous DMF is heated with K2CO3 (0.41 g, 3.0 mmole) at 80° C. for 16 hours. After removal of the solvent, the residue is purified on flash chromatography with EtOAc/Hexanes (0-15%), yielding yellow oil 1.05 g (4.0 mmole) 67% of benzyl-(2-fluoro-4-nitro-phenyl)-methylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718671B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-daa3474617cb416eb7d6d5773429612e |
| Source note | uspto-grants-2010_05 |