Lithium hydroxide, monohydrate → HCID 67026786, compound

Participants

Reaction Steps

(±)-{(1R,3aS,4R,6aS)-4-[4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]octahydropentalen-1-yl}malonic acid was prepared as follows. A solution of dimethyl(±)-{(1R,3aS,4R,6aS)-4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]octahydropentalen-1-yl}malonate (190 mg, 0.38 mmol) and lithium hydroxide monohydrate (166 mg, 3.9 mmol) in p-dioxane/water (8:3-11 mL) was stirred at 50° C. for 3 hours. The reaction was concentrated to remove the p-dioxane, water (2 mL) added and the mixture extracted with EtOAc (5 mL). The aqueous layer was adjusted to pH˜3 with 2N aqueous hydrochloric acid, the solids filtered and dried in vacuo to afford the title compound as a white solid, 179 mg. 1H NMR (400 MHz, DMSO-d6) δ 8.17 (s, 1H), 7.58 (br s, 2H), 7.13 (d, 2H), 7.10 (d, 2H), 4.57 (m, 2H), 3.95 (m, 2H), 3.08 (d, 1H), 2.64 (m, 1H), 2.39 (m, 2H), 2.24 (m, 1H), 1.87-1.10 (m, 7H). m/z=467.3 (M+1).

Provenance & Evidence