1-(4-Amino-3-fluorophenyl)pyrazin-2(1H)-one → 3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid [2-fluoro-4-(2-oxo-2H-pyrazine-1-yl)-phenyl]-amide

Participants

Reaction Steps

In analogy to example 1E 3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5carboxylic acid ethyl ester (example 1D) was reacted with 1-(4-amino-3-fluoro-phenyl)-pyrazine-2-one (CAS 863015-77-4) to give 3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid [2-fluoro-4-(2-oxo-2H-pyrazine-1-yl)-phenyl]-amide. Yellow solid. MS 475.0 ([M+H]−)

Provenance & Evidence