4-(4-Amino-3-fluorophenyl)morpholin-3-one → 3-{[(5-Chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

Participants

Reaction Steps

In analogy to example 1E 3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (example 1D) was reacted with 4-(4-amino-3-fluoro-phenyl)-morpholin-3-one (CAS 438056-69-0) to give 3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide. Light yellow solid. MS 462.0 ([M+H]−)

Provenance & Evidence