HCID 86613532, compound → HCID 59588942, compound

Participants

Reaction Steps

The solution of 0.185 g of tert-butyl {1(S)-(2-azido-1(S)-hydroxyethyl)-3(S)-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate in 6 ml of methanol is hydrogenated in the presence of 0.037 g of 10% Pd/C over 2 hours. The reaction mixture is clarified by filtration and concentrated by evaporation. The title compound is obtained from the residue by means of flash chromatography (SiO2 60F) as a slightly greyish oil. Rf=0.08 (200:20:1 dichloromethane-methanol-25% conc. ammonia); Rt=15.47 (gradient II).

Provenance & Evidence