(R)-(-)-alpha-methoxyphenylacetic acid → (R)-Cyclohexyl-methoxy-acetic acid

HRID 2237744Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2237744
[CH3:1][O:2][C@H:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=[O:5]>CO>[CH:7]1([C@@H:3]([O:2][CH3:1])[C:4]([OH:6])=[O:5])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

Komponenten

3

Edukt 1

HCID 2724294(R)-(-)-alpha-methoxyphenylacetic acid

Produkt 1

HCID 66888902(R)-Cyclohexyl-methoxy-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

An autoclave is charged with a solution of 1.00 g of (R)-α-methoxy-phenyl acetic acid in 20 ml methanol. 0.100 g of Nishimura catalyst are added and the mixture is hydrogenated at 4 bar and 20° C. for 1 hour. The mixture is filtered over Hyflo and the filtrate concentrated by evaporation to provide the title compound as a colourless oil. The crude material is used without further purification. Rf=0.84 (150:54:10:1 dichloromethane-methanol-water-acetic acid).

Aufarbeitung

  1. filtrationThe mixture is filtered over Hyflo
  2. concentrationthe filtrate concentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-b01b03d6f3924ff4ab11bcda95f2596e
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07718675B2

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