Sodium Hydroxide → HCID 57557633, compound

Participants

Reaction Steps

A mixture of diethyl 1,4-bis(ethyloxy)-6-fluoro-2,3-naphthalenedicarboxylate (2.5 g, 6.6 mmol), ethanol (50 ml) and sodium hydroxide (50 ml) was heated under reflux for 1 hour. The reaction mixture was cooled and concentrated in vacuo. This was acidified with 2N HCl (˜50 ml) and extracted with EtOAc (×2). Combined organics were washed with brine, dried over magnesium sulphate and concentrated in vacuo to give the title compound as a yellow solid (2.24 g).

Provenance & Evidence