Acetic Acid → HCID 13051490, compound

HRID 223777Notes

Reaction equation

HRID 223777 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](=[O:22])[NH:10][CH:11]=[C:12]3[C:17]=2[NH:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[S:13]3)=[CH:4][CH:3]=1.C(O)(=[O:25])C.C(OO)(=O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9](=[O:22])[NH:10][CH:11]=[C:12]3[C:17]=2[NH:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[S:13]3=[O:25])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6585Peracetic AcidHCID 13051480HCID 13051480, compound

Product 1

HCID 13051490HCID 13051490, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 3 parts of the product of the process described in Example 14, 4-(4-chlorophenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one, suspended in 5 parts acetic acid is added and 1 part 40% peracetic acid. After ten minutes reaction time, water is added to the now homogeneous reaction mixture and the precipitate which forms is collected and recrystallized from aqueous DMF to yield white needles of 4-(4-chlorophenyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one 10 oxide, melting above 310°.

Workup

  1. additionis added
  2. additionis added to the now homogeneous reaction mixture
  3. customthe precipitate which forms is collected
  4. customrecrystallized from aqueous DMF

Sources & evidence

ORD record
ord-d4ebf32bd0be4a0ab8e24f2fb0405c4f
Source dataset
uspto-grants-1982_10
Patent number
US04356302

Reaction notes

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