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HRID 2237991作成日：2026年10月25日

1-(4-Bromophenyl)ethanol → 1-(4-[7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-ethanol

https://huagongshe.com/reaction/2237991

反応式

関与物質

役割名称HCID仕込み量
反応物1-(4-Bromophenyl)ethanolHCID 95352—
反応物3-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidineHCID 71539732—
生成物1-(4-[7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-ethanolHCID 86608041—

反応手順

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1) (355 mg, 1.0 mmol) and commercially available 4-bromo-methylbenzylalcohol (181 mg, 1.0 mmol, [CAS 5391-88-8]) according to general procedure II. Obtained as an orange solid (115 mg, 24%). MS (ISP) 476.2[(M+H)+]; mp 175-178° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07718661B2
出典データセットuspto-grants-2010_05
ORD IDord-af50ed166f32467cbfdee7c7c5bbcc97
出典メモuspto-grants-2010_05