HRID2238008

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID27518037

未命名化合物

结构：C#Cc1cnn2c(C3CC3)cc(-c3ccc(Cl)cc3)nc12

HCID86607996

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C#Cc2cnn3c(C4CC4)cc(-c4ccc(Cl)cc4)nc23)cc1S(=O)(=O)NC(C)(C)CO

HCID11851619

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 5-(4-chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine (example C.5) (73 mg, 0.25 mmol) and 5-bromo-N-(2-hydroxy-1,1-dimethyl-ethyl)-2-methoxy-benzenesulfonamide (85 mg, 0.25 mmol) (Example B.7) according to general procedure II. Obtained as a yellow solid (38 mg, 28%). MS (ISP) 551.3[(M+H)+]; mp 253-256° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-920fcea6111e48eeb65da4d8d70045a7
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07718661B2
来源说明: uspto-grants-2010_05

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]#[CH:21])=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Br[C:23]1[CH:24]=[CH:25][C:26]([O:38][CH3:39])=[C:27]([S:29]([NH:32][C:33]([CH3:37])([CH3:36])[CH2:34][OH:35])(=[O:31])=[O:30])[CH:28]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]#[C:21][C:23]4[CH:24]=[CH:25][C:26]([O:38][CH3:39])=[C:27]([S:29]([NH:32][C:33]([CH3:36])([CH3:37])[CH2:34][OH:35])(=[O:31])=[O:30])[CH:28]=4)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1