5-Bromo-2,4-difluorobenzenesulfonamide → HCID 67001101, compound

HRID 2238009Notes

Reaction equation

HRID 2238009 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]#[CH:21])=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Br[C:23]1[C:24]([F:34])=[CH:25][C:26]([F:33])=[C:27]([S:29]([NH2:32])(=[O:31])=[O:30])[CH:28]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]#[C:21][C:23]4[C:24]([F:34])=[CH:25][C:26]([F:33])=[C:27]([S:29]([NH2:32])(=[O:30])=[O:31])[CH:28]=4)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27732955-Bromo-2,4-difluorobenzenesulfonamideHCID 866079965-(4-Chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 67001101HCID 67001101, compound

Procedure

The title compound was prepared from 5-(4-chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine (example C.5) (73 mg, 0.25 mmol) and 5-bromo-2,4-difluoro-benzenesulfonamide (68 mg, 0.25 mmol) according to general procedure II. Obtained as a yellow solid (91 mg, 75%). MS (ISP) 485.1 [(M+H)+]; mp 272-275° C.

Sources & evidence

ORD record
ord-9f154e19b866439bba3f400610f0a195
Source dataset
uspto-grants-2010_05
Patent number
US07718661B2

Reaction notes

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