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HRID 2238120作成日：2026年10月25日

1-(4-Bromophenyl)ethanol → 1-{4-[8-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-ylethynyl]-phenyl}-ethanol

https://huagongshe.com/reaction/2238120

反応式

関与物質

役割名称HCID仕込み量
反応物1-(4-Bromophenyl)ethanolHCID 95352—
反応物3-Ethynyl-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridineHCID 86608011—
生成物1-{4-[8-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-ylethynyl]-phenyl}-ethanolHCID 16735753—

反応手順

The title compound was prepared from 3-ethynyl-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine (example C.18) (360 mg, 1 mmol) and commercially available 4-bromo-methylbenzyl alcohol (184 mg, 1 mmol) according to general procedure II. Obtained as an off-white solid (65 mg, 13%). MS (ISP) 475.2 [(M+H)+]; mp 157-158° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07718661B2
出典データセットuspto-grants-2010_05
ORD IDord-aac5f34235dc4a7bb6f176dc76670799
出典メモuspto-grants-2010_05