2-Amino-5-bromopyridine-3-carbonitrile → HCID 86608100, compound

HRID 2238142Notes

Reaction equation

HRID 2238142 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)=[N:8][C:7]=12)#[CH:2].[NH2:26][C:27]1[N:34]=[CH:33][C:32](Br)=[CH:31][C:28]=1[C:29]#[N:30]>>[NH2:26][C:27]1[N:34]=[CH:33][C:32]([C:2]#[C:1][C:3]2[CH:4]=[N:5][N:6]3[C:11]([C:12]([F:14])([F:13])[F:15])=[CH:10][C:9]([C:16]4[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=4)=[N:8][C:7]=23)=[CH:31][C:28]=1[C:29]#[N:30]

Participants

3

Reactant 2

HCID 242291992-Amino-5-bromopyridine-3-carbonitrileHCID 715397323-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 86608100HCID 86608100, compound

Procedure

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1) (355 g, 1.0 mmol) and 2-amino-5-bromo-nicotinonitrile (example C.23 step 1) (200 mg, 1.0 mmol) according to general procedure II. Obtained as a red solid (280 mg, 59%). MS (ISP) 473.2 [(M+H)+]; mp 264° C.

Sources & evidence

ORD record
ord-30f172f19f154ce3ad25cf4b6a2690a5
Source dataset
uspto-grants-2010_05
Patent number
US07718661B2

Reaction notes

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